It didn’t make its debut in actual combat until 2014
Source: Taringa!
In July of that year, a U.S.-led coalition against ISIS began dropping bombs on targets within Syria and Iraq. A couple months later, the military enlisted the help of the F-22 to help ensure the safety of other aircraft involved in the air strikes.
Its role was to escort the strike packages within the target area, as well as gathering details about the enemy systems.